10.1002/anie.201808560
Angewandte Chemie International Edition
COMMUNICATION
transformation, relatively high catalyst loadings and reaction
temperatures leave room for improvement. Further efforts in the
design of tailored ligands will be needed to further establish cross-
coupling as an important strategy for derivatization of common
methyl esters.
Acknowledgements
Financial support for this work was provided by the University of
Ottawa, the National Science and Engineering Research Council
of Canada (NSERC), and the Canada Research Chair program.
The Canadian Foundation for Innovation (CFI) and the Ontario
Ministry of Economic Development and Innovation are thanked
for essential infrastructure. FQRNT and NSERC are thanked for
graduate scholarships (T.B.H. and J.M.M.).
Keywords: cross-coupling • nickel catalysis • C–O activation •
amides
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S4 and S5.
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