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In conclusion, we have developed an operationally simple
and efficient iron catalyzed domino decarboxylation-oxidation
of a,b-unsaturated carboxylic acids enabled aldehyde C–H
methylation for preparing diversified methyl ketones. This
two-stage methylation, rather than direct methylation, is help-
ful for product purification. This method is compatible with
sensitive functional groups, which will be damaged in oxida-
tion, ionic or polar reactions. Importantly, this toolbox can be
applied to the late-stage modification of complex small mole-
cules. Further work will be dedicated to the use of the method
for the synthesis of complex molecules and to study the
detailed mechanism.
The work was sponsored by the Natural Science Foundation
of China (21776139, 21302099), the Natural Science Foundation
of Jiangsu Province (BK20161553), the Natural Science Founda-
tion of Jiangsu Provincial Colleges and Universities (16KJB
150019), the China Scholarship Council, and the Priority
Academic Program Development of Jiangsu Higher Education
Institutions.
Conflicts of interest
There are no conflicts to declare.
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