Tetrahedron Letters p. 339 - 342 (1997)
Update date:2022-09-26
Topics:
Ward, Dale E.
Lazny, Ryszard
Soledade
Pedras
An efficient synthesis of the cyclic hexdepsipeptide destruxin B from its component residues is described that involves a [3+3] fragment coupling followed by cyclization via the azide method. A novel feature of the synthesis is the use of the Boc-hydrozide protecting group for the C-terminal N-methylalanine residue. This group serves bath to inhibit facile diketopiperazine formation from the N-methylvalyl-N-methylalanine dipeptide and as a latent activating group for hexadepsipeptide cyclization.
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