Angewandte Chemie - International Edition p. 12888 - 12891 (2017)
Update date:2022-07-29
Topics:
Sib, Anna
Gulder, Tobias A. M.
Natural products are a virtually inexhaustible source of small molecules with spectacular molecular architectures and biomedical potential. Their structural complexity generates formidable challenges to total synthesis but often also precludes time- and resource-efficient, stereoselective synthetic access. Biosynthetically, nature frequently uses dimerization and oligomerization reactions to produce highly challenging frameworks from simple starting materials. Impressive examples are the bisorbicillinoids, a family of fungal natural products thought to originate from the polyketide precursor sorbicillin. Utilizing the recombinant oxidoreductase SorbC from the sorbicillin biosynthetic gene cluster, a robust, fully stereoselective synthesis of bisorbicillinoid natural products and unnatural side-chain analogues was developed.
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Doi:10.1016/S0008-6215(03)00349-5
(2003)Doi:10.1039/c7sc01276d
(2017)Doi:10.1016/j.bmcl.2008.03.021
(2008)Doi:10.1248/cpb.33.2688
(1985)Doi:10.1021/ol8006277
(2008)Doi:10.1002/hlca.200890057
(2008)