10.1002/anie.201914089
Angewandte Chemie International Edition
COMMUNICATION
optimized condition, affording N-Boc protection amines.[19] As the
direct conversion of amines, CO/O2 with steric tertiary alcohols
has proven to be difficult and no effective catalyst systems
reported, till recently, the synthesis of N-Boc-protected amines is
via the reaction of secondary amines with (Boc)2O,[20] which is
commonly prepared by the reaction of toxic phosgene or its
derivatives with tert-butanol.[21] Thus in consideration of the whole
process, the preparation of N-Boc protected amines by (Boc)2O
belongs to a phosgene-mediated route; beyond that more than a
half of atoms in (Boc)2O were wasted as by-products (tert-butanol
and carbon dioxide). Alternatively, the ready availability of the
substrates (amines, tert-butanol, CO and air) makes this
[Au(NHC)2][CuI2]-catalyzed carbonylative protocol attractive for
generating a series of N-Boc protected amines derivatives.
The authors declare no conflict of interest.
Keywords: amine-responsive, synergistic catalysis,
supramolecular chemistry, oxidative carbonylation, urea and
carbamates
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The work was supported by NSFC (91645118, 21633013,
21802151, 21703159) and NSF of Jiangsu Province
(BK20180249). L.H. thanked Key Research Program of Frontier
Sciences of CAS (QYZDJ-SSW-SLH051). Y.C. acknowledged
the grant from the Strategic Priority Research Program of CAS
(XDB17000000) and CAS-Croucher Funding Scheme for Joint
Laboratories. Ms. Ying Ma was acknowledged for HRMS. Thanks
go to Profs. Aiwen Lei, Fuwei Li and Senmiao Xu for sharing
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Conflict of interest
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