Journal of Organic Chemistry p. 3093 - 3098 (1986)
Update date:2022-08-04
Topics:
Cheng, Jane Chi-Ya
Hacksell, Uli
Daves, G. Doyle
C-Nucleosides, of either α or β configuration, are formed selectively in a palladium-mediated coupling reaction between furanoid glycals and (1.3-dimethyl-2,4-dioxo-1,3-dihydropyrimidin-5-yl)mercuric acetate.Control of anomeric configuration is accomplished by suitable choice of substituents for glycal 3-O- and 5-O-hydroxy groups; attack of organopalladium reagent and glycosidic bond formation occurs on the least sterically hindered face of the glycal ring.Removal of substituents from the coupled products yielded 2'-deoxy-3'-keto C-nucleosides, which upon metal hydride reduction produced the corresponding 2'-deoxy C-nucleosides.
View MoreHangzhou Dawn Ray Pharmaceutical Co.,Ltd
website:http://www.dawnraypharma.com/
Contact:+86-571-85335020
Address:1018 Guangyin Building,No.42 E.Fengqi Road,Hangzhou,310012 China
Chengdu NoVi Biotechnology Co., Ltd.
Contact:13551243286/028-81458053
Address:NO.168-1-224 JULONG ROAD WUHOU DISTRICT, CHENGDU CITY,SICHUAN PROVINCE
Contact:86-25-84683399
Address:605, Phoenix Herui Plaza, No.389, South Taiping Road, Nanjing, China 210002
Contact:
Address:308# dongwu avenue dongxihu district wuhan city
Contact:15973022782
Address:7-5-6218,Incubation Centre,Guandong Industry Park, East Lake High-Tech Development Zone,Wuhan City.
Doi:10.1016/S0040-4039(00)96368-8
(1987)Doi:10.1055/s-1985-31369
(1985)Doi:10.1007/s11745-002-0931-1
(1957)Doi:10.1016/0008-6215(86)80048-9
(1986)Doi:10.1016/0022-328X(85)88057-8
(1985)Doi:10.1002/chem.201603664
(2016)