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reaction can be carried out on gram scale in almost the same
yields. The wide availability of reagents implies that an extensive
range of substituents can be selectively incorporated into the
pyrimidine ring. Taking into account that the starting materials
are readily available and in view of potential applications of the
products, this method is highly promising in organic synthesis
and medicinal chemistry.
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This work was financially supported by the Russian Foundation
for Basic Research and the Moscow City Government in the
framework of the research project No. 15-34-70030
“mol_а_mos”.
Keywords: pyrimidine, • β‑chlorovinyl aldehyde • ambident
electrophile • heterosteroids
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