Communication
RSC Advances
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Scheme 3 Scope of aryl boronic acid in the room-temperature Suzuki
coupling with 2-chloro-5-(trifluoromethyl) pyridine (2k).
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Scheme 4 Room-temperature Suzuki coupling of 3-chloropyridine
with 4-methoxyphenylboronic acid on gram scale.
Suzuki cross coupling of aryl chlorides without chelating with
nitrogen atom in pyridine.
´
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In summary, Pd(OAc)2/Nixantphos-catalyzed Suzuki–
Miyaura cross-coupling reaction of aryl-boronic acids with aryl
chlorides were realized at room temperature in high yields
(average yield >90%). In our method, a broad range of
substrates could be adopted to afford diverse products with
minor limitations. The success of this method attributes to the
application of commercially available ligand NiXantphos. Next,
we will continue our exploration for cross coupling reaction of
aryl chlorides using NiXantphos as ligand.
Acknowledgements
We thank the NSFC (no. 31570341) and Key Technology Support
Program of Scihuan Provice, China (no. 2015SZ0105) for
nancial support.
Notes and references
1 K. Sambasivarao, L. Kakali and K. Dhurke, Tetrahedron,
2002, 58, 9633.
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RSC Adv., 2015, 5, 107119–107122 | 107121