Chemical and Pharmaceutical Bulletin p. 1076 - 1083 (1994)
Update date:2022-08-03
Topics:
Refouvelet
Harraga
Nicod
Robert
Seilles
Couquelet
Tronche
A series of 6,8-dioxo-3-thia-1,7-diazabicyclo[3.3.0]octanes and a series of 6,8-dioxo-3-thia-1,7-diazabicyclo[3.3.0]octane 2-spiro derivatives were synthesized from L-(-)-R-cysteine ethyl ester in two steps. The synthetic route involved condensation of the amino acid with an appropriate aldehyde or ketone, then a further condensation of the resultant ethyl thiazolidine-4- carboxylate with an isocyanate or an isothiocyanate. The proliferative response to human lymphocyte mitogen (phytohemagglutinin) was used as a primary screening assay for most of the thiadiazabicyclic compounds in comparison with levamisole. Furthermore, the most active compounds were tested for ability to release soluble receptors (sRIL-2) after mitogenic stimulation of T cells and for ability to activate macrophage oxidative metabolism measured by chemiluminescence. Most compounds were active in all three tests and some showed dose-dependent activity.
View MoreSHANDONG QINGYUNCHANGXIN CHEMICAL SCIENCE-TECH CO.,LTD
Contact:86-21-60560171
Address:1689Donghuan Rade,Qingyun County, Dezhou City, Shandong,China
Contact:+86-574-87642758
Address:Room 901, Yinyi Bund Building, 132 Renmin Road
KangZhiYuan Pharmaceutical Company Limited
Contact:(Sabrina)86-20-85273232
Address:4th floor, building B, Dadi industry zone, Tangxia, Tianhe, Guangzhou, China
Shandong Ailitong New Material Co.,Ltd
Contact:+86-536-3226266
Address:zhongjia village, putong town , qingzhou city,Shandong Province,China
Laohekou Jinghong Chemical Co.,Ltd
Contact:+86-0710-3702747
Address:163.East,Huagong Road,Laohekou
Doi:10.1135/cccc19942069
(1994)Doi:10.1016/j.jorganchem.2008.04.038
(2008)Doi:10.1016/S0040-4039(00)84265-3
(1986)Doi:10.1021/je00047a039
(1987)Doi:10.1021/jm00015a019
(1995)Doi:10.1021/jo00106a021
(1995)