Medicinal Chemistry Research p. 103 - 113 (2008)
Update date:2022-08-04
Topics:
Bhandari, Kalpana
Srinivas, Nagarapu
Sharma, Lata
Srivastava, Shipra
Nath, Amar
Nath, Chandishwar
A series of urea and thiourea analogues of fluoxetine (5-17) were synthesized and evaluated for their anorexigenic and antidepressant activities. The related conformationally restrained analogues (20-23) were also prepared for structure-activity relationship (SAR) studies. Many of these derivatives (5, 6, 8, 10, 12, 13, 16, and 23) exhibited significant anorexigenic activity and interestingly were devoid of antidepressant activity, thus emerging as a promising tool for further research work.
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