Quantitative Comparison of Chiral Catalysts Selectivity and Performance
CDMO and other BVMOs to complete record sets used.
F.R. sparked the idea of quantitative catalyst ranking. M.J.F.
developed and implemented all necessary methods – statisti-
cal and graphical. F.R. programed the open-source
MATLAB script provided in electronic form. M.D.M. con-
ceptually designed the substrate profiling program for
BVMOs as well as approaches to link biocatalyst perfor-
mance with biochemical properties of enzymes. M.D.M.,
M.J.F. and F.R. co-wrote the manuscript. All authors com-
mented on the manuscript.
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[15] CDMO from Rhodococcus ruber SC1, CHMO from
Acinetobacter calcoaceticus NCIMB 9871, CHMO from
Arthrobacter sp. BP2, CHMO from Brachymonas pet-
roleovorans, two CHMOs from Brevibacterium epider-
mis HCU, CHMOs from Rhodococcus pyridinovorans
Phi1 and Rhodococcus ruber Phi2, CHMO from Xan-
thobacter sp. ZL5 and CPMO from Comamonas sp.
NCIMB 9872. References for isolation and cloning in
recombinant hosts can be found in the Supporting
Information.
Acknowledgements
[16] A. J. Albrecht, in: Proceedings of the Joint SHARE,
GUIDE and IBM Application Development Symposi-
um, Monterey, CA, 1979, pp 83–92
[17] Detailed biotransformation data was partly obtained
from published records and new data and can be found
in the Supporting Information.
We thank Prof. Dr. Peter Filzmoser with the Institute of Sta-
tistics and Probability Theory, Vienna University of Technol-
ogy, for valuable advice and critical assessment of our work.
M.J.F. is generously funded by EU-FP7 within the project
OxyGreen (grant no. 212281). D.V.R. was funded by the Aus-
trian Science Fund FWF (project number P-18945). At pres-
ent D.V.R. is a staff member of Consejo Nacional de Investi-
gaciones Cientꢀficas y Tꢁcnicas (CONICET), Argentina.
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