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4. Eight-membered rings as part of a bridged system are found in the taxols:
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ring-closing metathesis strategy combined with late-stage amine
derivitization with common pharmacophores. Other libraries
based on medium-ring templates are in progress and will be re-
ported as developments warrant.
5. Tapiolas, D. M.; Roman, M.; Fenical, W.; Stout, T. J.; Clardy, J. J. Am. Chem. Soc.
1991, 113, 4682.
Acknowledgments
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We acknowledge support of this work by the National Institutes
of Health (The University of Kansas Chemical Methodology and Li-
brary Development Center of Excellence), P50 GM069663. We
thank Mr. Benjamin Neuenswander from the KU-CMLD Library De-
sign and Analysis Core for performing HRMS and LC–MS analysis.
Additional support from the Howard Hughes Medical Institute
(Biological Sciences Education Grant, KSU) and the Terry C. Johnson
Center for Basic Cancer Research, KSU) is hereby acknowledged.
References and notes
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