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development of much-needed new anti-trypanosomal drugs espe-
cially when coordinated to metal ions.
Complex (3) besides displaying higher efficacy than its corre-
sponding thiosemicarbazone ligand upon bloodstream trypom-
astigotes, was 18-fold more effective than the Mn(II) salt. In
addition, complex(3) showed the highest selective index, being
as much as 10-fold more active against the trypanosomes than
against the cardiac cells. Thus, the present study supports previous
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The present study was supported by Fiocruz and by Fundação
Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Ja-
neiro (FAPERJ, E-26/111.550/2008), Conselho Nacional Desenvolvi-
mento Científico e Tecnológico (CNPq) and PAPES V/FIOCRUZ. The
authors thank Dr. Solange Lisboa de Castro for careful revision of
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