Chemistry - A European Journal p. 9090 - 9100 (2018)
Update date:2022-09-26
Topics:
Schoene, Jens
Bel Abed, Hassen
Schmieder, Peter
Christmann, Mathias
Nazaré, Marc
A simple and direct approach for the regioselective construction of the privileged 2H-indazole scaffold is described. The developed one-pot strategy involves phospholene-mediated N?N bond formation to access 2H-indazoles. The amount of organophosphorus reagent was minimized by recycling the phospholene oxide with organosilane reductants. Starting from functionalized 2-nitrobenzaldehydes and primary amines, a mild reductive cyclization, involving the use of commercially available phospholene oxide and silanes, delivered a wide variety of substituted 2H-indazoles in good to excellent yields.
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