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LETTER
Ley, S. V. Org. Process Res. Dev. 2007, 11, 399.
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M.; Baxendale, I. R.; Ley, S. V.; Smith, C. D.; Tranmer, G.
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(11) Vapourtec R2+/R4 units are available from Vapourtec Ltd,
Place Farm, Ingham, Suffolk, IP31 1NQ, UK. Website:
leyitc.ch.cam.ac.uk/equipment.html for images of the
equipment.
(12) Commercially available Omnifit® glass chromatography
columns with adjustable height-end pieces(plunger).
Typically, the polymer-supported reagent is placed in an
appropriately sized Omnifit® column, usually 10 mm bore
by 150 mm length, or shorter and the plungers are adjusted
to relevant bed heights and the polymer swelled/washed with
(4) (a) Gustafsson, T.; Gilmour, R.; Seeberger, P. H. Chem.
Commun. 2008, 3022. (b) Singh, R. P.; Meshri, D. T.;
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M. In Organic Reactions, Vol. 35; John Wiley and Sons:
New York, 1988, 513.
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Smith, C. D. Heterogeneous Reactions, In Microreactors in
Organic Chemistry and Catalysis; Wirth, T., Ed.; Wiley-
VCH: Weinheim, 2008, Chap. 4.2, 84–122.
(6) (a) Baxendale, I. R.; Deeley, J.; Griffiths-Jones, C. M.; Ley,
S. V.; Saaby, S.; Tranmer, G. K. Chem. Commun. 2006, 24,
2566. (b) Baxendale, I. R.; Griffiths-Jones, C. M.; Ley, S.
V.; Tranmer, G. K. Synlett 2006, 427.
(13) Available from Macherey-Nagel GmbH & Co. Dueren,
Germany.
(14) Lal, G. S.; Pez, G. P.; Pesaresi, R. J.; Prozonic, F. M.; Cheng,
H. J. Org. Chem. 1999, 64, 7048.
(15) Oxazoline synthesis in the total synthesis of (–)-hennoxazole
A: Ley, S. V. unpublished results.
(16) Tse, M. K.; Bhor, S.; Klawonn, M.; Anilkumar, G.; Jiao, H.;
Döbler, C.; Spannenberg, A.; Mägelein, W.; Hugl, H.;
Beller, M. Chem. Eur. J. 2006, 12, 1855.
(17) Phillips, A. J.; Uto, Y.; Wipf, P.; Reno, M. J.; Williams, D.
R. Org. Lett. 2000, 2, 1165.
Synlett 2008, No. 14, 2111–2114 © Thieme Stuttgart · New York