Journal of Organic Chemistry p. 3409 - 3413 (1987)
Update date:2022-09-26
Topics: Synthesis Structural Aspects (2,5)-1,3,4-Thiadiazolo (3,5)-1,3,4-Thiadiazolino Thia Crown Ethers
Pappalardo, Sebastiano
Bottino, Francesco
Tringali, Corrado
Fronczek, Frank R.
A general route to (2,5)-1,3,4-thiadiazolo thia crown ethers 3, by the high-dilution reaction of 2,5-dimercapto-1,3,4-thiadiazole dipotassium salt 8 with oligoethylene glycol dihalides 9 in ethanol, is described.The reaction of 8 with bis<2-(2-bromoethoxy)ethyl> ether (9c) produced also small amounts of the 15-membered (3,5)-1,3,4-thiadiazolino thione macrocycle 10, which possesses a ring nitrogen pointing into the complexing cavity.The structures of the macrocycles were firmly established by 1H and 13C NMR spectroscopy.Macrocycle 10 was further characterized by a single-crystal X-ray diffraction study.
View MoreHunan Zhongqi Pharmaceutical Co., Ltd
website:http://www.hnzqzy.com
Contact:0730-8722288 13807308622
Address:Wanjiafan Road ,Yueyang Economic And Technological Development Zone ,Hunan,PRC
Contact:86-25-58619180
Address:Nanjing High-Tech Zone 10 Xinghuo Road Pukou District Nanjing, Jiangsu 210061 The People's Republic of China
Contact:+86-021-58123769
Address:No.780 of Cailun Road,Zhangjiang Hi-tech Park,Pudong,Shanghai
CGeneTech (Suzhou, China) Co., Ltd.
Contact:+86-512-62956962
Address:Room 101,Bld C11,218 Xinghu Rd.,Suzhou industrial Park
Contact:+86-158-05817090
Address:ROOM 9F, FLAT 2, GUODU DEVELOPING BLDG, No.182, ZHAOHUI ROAD
Doi:10.1021/jo00392a021
(1987)Doi:10.1002/hlca.19460290321
(1946)Doi:10.1002/chem.200800510
(2008)Doi:10.1016/j.jcat.2018.06.012
(2018)Doi:10.1021/ja111389r
(2011)Doi:10.1002/jhet.5570230645
(1986)