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11. Oxidation of (S)-3-(methylthio)pyrrolidine-3-carboxylate 50 with
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compound 29
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16. methyl (S)-3-(methylthio)pyrrolidine-3-carboxylate 50:1H NMR
(599 MHz, DMSO-d6): δ 3.98 (s, 1H), 3.69 (s, 2H), 3.53 (d, J =
12.4 Hz, 1H), 3.23 – 3.10 (m, 2H), 2.41 (dt, J = 13.7, 8.2 Hz, 1H),
2.02 – 1.94 (m, 1H). 13C NMR (151 MHz, DMSO-d6): δ 173.81,
170.95, 71.40, 55.39, 52.45, 52.25, 44.41, 33.67, 12.95.
17. (S)-N-(3-(4-fluorophenyl)-1H-indazol-5-yl)-3-(methylthio)-1-(2-
oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)-3,6-dihydropyridin-1(2H)-
yl)ethyl)pyrrolidine-3-carboxamide 28: 1H NMR (599 MHz,
DMSO-d6): δ 13.21 (s, 1H), 10.61 (s, 1H), 10.20 – 9.89 (m, 1H),
8.88 (d, J = 4.6 Hz, 2H), 8.42 – 8.29 (m, 3H), 7.93 (m, 3H), 7.69
(dd, J = 8.9, 1.7 Hz, 1H), 7.64 – 7.54 (m, 3H), 7.41 (t, J = 4.7 Hz,
1H), 7.36 (m, 3H), 6.34 (m, 1H), 4.57 (m, 3H), 4.28 – 4.17 (m,
2H), 4.12 (d, , 1H), 3.98 (m, 1H), 3.91 – 3.78 (m, 1H), 3.76 (m,
1H), 3.67 – 3.25 (m, 3H), 2.97 – 2.52 (m, 4H), 2.44 – 2.30 (m,
1H), 2.14 (s, 3H). 13C NMR (151 MHz, DMSO-d6): δ 168.16,
163.40, 163.17, 162.83, 162.38, 160.75, 157.50, 141.95, 141.57,
138.77, 136.02, 135.99, 134.25, 133.85, 132.25, 130.15, 128.28,