Archiv der Pharmazie p. 661 - 664 (2008)
Update date:2022-09-26
Topics:
Yun, Jeong Choe
Han, Na Seo
Soo, Yeon Jung
Rhim, Hyewhon
Kim, Jungahn
Dong, Joon Choo
Jae, Yeol Lee
3,4-Dihydroquinazoline derivatives have been known to be the novel and potent T-type calcium channel blockers. From a systematic variation of 3,4-dihydroquinazoline derivative 5c (KYS05043), plausible SAR results were established. It was revealed that a 5-(dimethylamino)pentylamino group at R 1, a biphenyl group at R2, and a benzyl amido group at R3 in the 3,4-dihydroquinazoline backbone are closely related with the channel selectivity (T/N-type) as well as the potency based on the discovery of 6k (KYS05090).
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Doi:10.1016/j.tetlet.2008.09.098
(2008)Doi:10.1021/jo01355a006
(1957)Doi:10.1248/cpb.35.1666
(1987)Doi:10.1139/v57-054
(1957)Doi:10.1039/c9cc02659b
(2019)Doi:10.1080/10426500701566980
(2008)