10.1002/chem.201802465
Chemistry - A European Journal
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amino esters, amino monoesters and amino bis-esters, react
with a diverse range of simple aryl and heteroaryl iodide
reagents to provide a rapid access to unnatural amino acids
from readily available materials. Further synthetic applications
and additional mechanistic studies are currently under
investigation in our laboratory and will be reported in due course.
Acknowledgements
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We thank Scott J. Novick for HRMS analysis.
Keywords: unnatural amino acids • free amino esters •
Transient Directing Group • γ-C-H arylation • Pd-catalysis
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