4
Tetrahedron
8.
Mohamed T., Hosahalli S., Panigrahi S.K., PCT Int.Appl.
WO/2013/148537A1; Chem. Abstr. 2013
In summary, we report the application of a palladium
catalysed cyclisation-cross coupling cascade to synthesise
benzopyran/oxetane spirocycles together with biaryl
containing oxetane/azetidines in moderate to good yields.
Oxetane/azetidine-pyrrolidino isoindolone spirocycles were
9.
Grigg R, Sridharan V. Pure Appl. Chem. 1998; 70: 1047; Grigg R,
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also synthesised via
a
silver-catalysed 1,3-dipolar
cycloaddition reaction followed by a palladium catalysed
carbonylation-amination process in good yields.
10. Smith SA, Hand KE, Love ML, Hill G, Magers DH. J. Comput.
Chem. 2013; 34: 558; Dorofeeva OV, Mastryukov VS, Vilkov
LV, Hargittai I. J. Chem. Soc. Chem. Commun. 1973; 20: 772.
11. Stereochemistry confirmed by NOE studies performed by Jones et
al. on analogous cycloadducts. Results are shown in the ESI.
12. Grigg R, Sridharan V. Adv. in Cycloaddition 1993; 3: 161;
Coldham I, Hufton R. Chem. Rev. 2005; 105: 2765; Najera C,
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Notes and References
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Burkhard JA, Wuitschik G, Rogers-Evans M, Muller K, Carreira
EM. Angew. Chem. Int. Ed. 2010; 49: 9052.
Wuitschik G, Rogers-Evans M, Muller K, Fischer H, Wagner B,
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2010; 53: 3227.
13. Wu, XF Neumann H, Beller M. Chem. Rev. 2013; 113: 1-35
14. Deposition number for compound 20a CCDC 1849751 contains
the supplementary crystallographic data for this structure. This
data can be obtained free of charge from the Cambridge
3.
4.
5.
Edward JT, Farrell PG, Shahidi P. J. Chem. Soc. Farady. Trans.
1977; 73: 705.
Crystallographic
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Magiatis P, Melliou E, Skaltsounis AL, Mitaku S, Leonce S,
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Chen, L., Feng, L., Feng, S., Gao, L., Guo, T., Huang, M., Liu, C.,
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WO/2013/020993; Chem. Abstr. 2013
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