Bioorganic and Medicinal Chemistry Letters p. 2900 - 2904 (2008)
Update date:2022-08-03
Topics:
Park, Heuisul
Min, Kyeongsik
Kwak, Hyo-Shin
Koo, Ki Dong
Lim, Dongchul
Seo, Sang-Won
Choi, Jae-Ung
Platt, Bettina
Choi, Deog-Young
We describe synthesis and evaluation of a series of cyclic urea derivatives with hydroxylethylamine isostere. Modification of P3, P1, and P2′ and combination of SAR display a >100-fold increase in potency with good cellular activity (IC50 = 0.1
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Doi:10.1002/ejoc.201500796
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