Journal of Medicinal Chemistry p. 1489 - 1492 (1988)
Update date:2022-09-26
Topics:
Joslyn, Alan F.
Luchowski, Elizabeth
Triggle, David J.
A series of 1,n-alkanediylbis(1,4-dihydropyridines) (n = 2, 4, 6, 8, 10, 12) bridged at C3 of 2,6-dimethyl-3-carboxy-5-carbethoxy-4-(3-nitrophenyl)-1,4-dihydropyridine were synthesized and evaluated in a radioligand binding assay, <3H>nitrendipine in intestinal smooth muscle, as C2+ channel ligands.Binding activity was comparable to that of nitrendipine itself but independent of chain length, suggesting the lack of a major binding contribution by the second 1,4-dihydropyridine group.Analogues lacking the second 1,4-dihydropyridine nucleus or possessing an inactive function (4-nitrophenyl) were no less active, confirming that this series of ligands likely does not bridge adjacent 1,4-dihydropyridine receptors of the Ca2+ channel.
View MoreContact:13357117572
Address:No.149 Shiji dadao Road.
Zhuzhou Farshine Chemical Industry Co., Ltd
Contact:0086-731-28482786
Address:No. 1,Shui Xian Road, He Tang Dictrict,Hunan-412000,China
TIANJIN DONGRUXIANG MINERALS MARKETING CO.,LTD
Contact:22-58516360
Address:tianjin
Zhejiang Chemline International Co., Ltd.
Contact:+86-571-88062298
Address:Hengdian Industry Area, Dongyang, Zhejiang, China
Puyang Huicheng Electronic Material Co., Ltd
website:http://huichengchem.weba.testwebsite.cn/index_en.html
Contact:+86-393-8910800
Address:West Section Shengli Road, Puyang457000, China
Doi:10.2174/157017809790442970
(2009)Doi:10.1007/BF00486914
(1987)Doi:10.1016/j.tetlet.2005.05.133
(2005)Doi:10.1055/s-2004-831212
(2004)Doi:10.1021/jo00249a035
(1988)Doi:10.1039/b900013e
(2009)