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weight of DIO C57BL/6J mice by 4% and 8%, respectively.
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observed and the NOE-correlation between H-oxime and H-inner benzene in
anti-oxime 2h was obtained. Regarding the geometry of other alkyl oximes
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difluorobenznene or H-inner aromatic supported the assignment of 3a, anti-
3a, 3b, anti-3b, 4b and anti-4b.
Acknowledgments
We would like to thank Dr. Shigeru Nakajima for performing
NOE studies and Atsushi Hirano for selecting HPLC conditions for
the separation of the oxime geometric isomers. We also thank
Dr. Peter T. Meinke (Merck Research Laboratories, Rahway, NJ)
for the editing of this manuscript.
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