Journal of Organic Chemistry p. 1744 - 1749 (1990)
Update date:2022-08-04
Topics:
Murahashi, Shun-Ichi
Oda, Tetsuya
Sugahara, Toshiaki
Masui, Yoshiyuki
The sodium tungstate catalyzed oxidation of 1,2,3,4-tetrahydroquinolines (1) with 30percent aqueous hydrogen peroxide solution in methanol gives 1-hydroxy-3,4-dihydroquinolin-2(1H)-ones (2), which are important biologically active compounds, in good to excellent yields.The cyclic hydroxamic acid 7 is also obtained in good yield.Since reduction of 2 thus obtained gives 3,4-dihydroquinolin-2(1H)-ones (4), the present reaction provides a convenient method for synthesis of 4 from 1.
View MoreHangzhou Share Chemical Co., Ltd
Contact:+86-57187093700
Address:Hang Xing Road
website:http://www.sjc.com.tw
Contact:(886) 2-2396-6223
Address:14Fl., No. 99. Sec. 2, Jen Ai Road
website:http://www.easchem.com
Contact:+86-731-89722861 89722891
Address:2/F-4/Bld Colorful Palace, No.605 Changsha Ave, Yuhua Area Changsha Hunan China.
Tianjin SPHINX SCIENTIFIC LAB.
Contact:+86-022-66211289
Address:Tianda high-tech Park. No.80,the 4th Avenue
Contact:+86-574- 87178138; 87297407
Address:No. 809, Liudingxingzuo, cangsong road, Ningbo, China
Doi:10.1039/P19880002271
(1988)Doi:10.1016/j.bmcl.2011.12.088
(2012)Doi:10.1021/np900158f
(2009)Doi:10.1080/00397910902793877
(2009)Doi:10.1039/jr9570000819
(1957)Doi:10.1039/jr9510002462
(1951)