10.1002/chem.201905048
Chemistry - A European Journal
COMMUNICATION
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Scheme 1. 10 g-scale synthesis
In summary, we have identified a procedurally simple use of a zinc
packed column as an alternative reductant to photo- or
electrochemical reactor or organometallic reagents for forging
C(sp3)-C(sp2) bonds starting from aryl halides and redox-active
esters. The method is practical and robust, and provides
enhanced substrate compatibility over previously reported
examples. Furthermore, the use of crude redox-active esters
accelerated the synthesis of highly 3D-rich structures from
carboxylic acids and (hetero)aryl halides. Notably, the work
features the ease of scale up by harnessing continuous flow
conditions.
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Y. C. thanks Pfizer for funding the postdoctoral fellowship. The
authors also gratefully acknowledge financial support from
H2020-FETOPEN-2016-2017
commission (SVL; grant agreement number: 737266-ONE
FLOW).
programme
of
European
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Keywords: Continuous flow, redox-active ester, cross-coupling,
packed-column
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