10.1002/chem.201903850
Chemistry - A European Journal
FULL PAPER
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This report contains two examples of aryl alkyl alkynes as substrates.
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solvent was added. After addition of all components the reactions were
stirred at room temperature for 2 min. The autoclave was purged with N2
(1 x 1 bar, 3 x 10 bar) before the reaction vessels were placed in an
autoclave under a counterflow of N2. Afterwards the autoclave was purged
with N2 (3 x 10 bar) and H2 (3 x 10 bar) before the appropriate H2 pressure
was applied (pressure is given as initial pressure before heating). The
heating block was pre-heated to the temperature given before the
autoclave was placed inside. After the reported reaction time the autoclave
was allowed to cool to room temperature and H2 was released. The
autoclave was purged with N2 (3 x 10 bar) before the reaction vessels
were taken out. The reaction mixture was concentrated under reduced
pressure, diluted with CH2Cl2 and filtered through a small plug of silica
(2 cm ø, 2 mL, CH2Cl2 as eluent), and all volatiles were removed under
reduced pressure. Reactions were subsequently analyzed either by GC
1
and/or H NMR. The crude mixture was then subjected to purification as
indicated with the appropriate substrates.
Acknowledgements
This work was supported by the German Research Council (DFG,
Emmy Noether Fellowship for J. F. T., TE1101/2-1) and by the
Fonds der Chemischen Industrie (Liebig-Stipendium for J. F. T.).
Prof. Dr. Martin Oestreich (TU Berlin) is kindly thanked for
generous support.
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Keywords: nickel • hydrogenation • alkyne • stereoselectivity •
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