European Journal of Medicinal Chemistry p. 55 - 60 (1989)
Update date:2022-08-02
Topics:
Moussavi, Ziaeddine
Lesieur, Daniel
Lespagnol, Charles
Sauzieres, Jacques
Olivier, Philippe
7-Acyl-2,3-dihydro-1,4-benzoxazin-3-ones and normolipemic properties.Fibrates are still among the most widely used drugs for the treatment of dyslipoproteinemia. 7-Acyl-2,3-dihydro-1,4-benzoxazin-3-ones (Fig.1B) can be considered as conformationally restrained analogues of fibrates, such as fenofibrate.These compounds have been prepared and studied for their normolipemic activity particularly on plasma cholesterol, triglyceride and high density lipoprotein (HDL) cholesterol levels.Hepatotoxicity and mutagenicity have also been evaluated.Some of them show an interesting activity, quite comparable to fenofibrate, and are devoid of hepatotoxicity. hyperlipidemia / hypocholesterolemic drugs / fibrates / 7-acyl-1,4-benzoxazin-3-ones
View MoreTengzhou Runlong Fragrance Co., Ltd.
website:http://www.tzrunlong.com/
Contact:0086-15665710862
Address:No. 78, Fushan Road, Biomedical Industrial Park, Dawu Town, Tengzhou, Shandong, 277514 China
China Synchem Technology Co.,Ltd
website:http://www.cnsynchem.com
Contact:+86-0552-4929311
Address:No.217 Daqing Road
MTT Pharma & Bio-technology Co.,Ltd
Contact:+86-21-58407925
Address:Room2019, Building C, Tomson Center, No.158, Zhang Yang Road, Shanghai, China
website:http://www.finetechnology-ind.com
Contact:86-27-87465837
Address:wuhan
Zhengzhou Minzhong Pharmaceutical Co.,ltd
Contact:0086-371-65797115
Address:15/F,Jiangshan Bldg, NO.126 Huanghe Road,Zhengzhou, China
Doi:10.1016/j.bmcl.2009.03.137
(2009)Doi:10.1016/S0022-1139(00)80124-4
(1991)Doi:10.1021/acs.joc.8b01161
(2018)Doi:10.1002/anie.201307174
(2013)Doi:10.1021/ja00390a046
(1982)Doi:10.1021/jm00328a034
(1965)