Synthetic Communications p. 1611 - 1625 (2009)
Update date:2022-09-26
Topics:
Xu, Lin
Muller, Marc R.
Yu, Xiong
Zhu, Bao-Quan
A short, elegant, and high yielding synthesis of ravoconazole is presented. The key step of this synthesis is an enantioselective palladium-catalyzed chiral zinc-allene addition reaction. The starting materials are 2-chloro-1-(2,4-difluorophenyl)-ethanone and (R)-4-phenylbutyn-2-ol obtained from enzymatic resolution of its racemate. Copyright Taylor & Francis Group, LLC.
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