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exposure biomonitoring.
Analytical Chemistry
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1
Conclusion
2
3
4
5
6
7
8
9
The method described here is rugged, precise, accurate, and
little labor-intensive. Results from the pilot population, give
reason to expect that OC metabolites can be determined in the
vast majority of urine samples from the general population,
even in case of background exposures (i.e. no recent use of
sunscreens). Urinary excretion factors of the three metabolites
in conjunction with the method described here, will allow for a
precise internal OC exposure and risk assessment, independent
of uptake routes and exposure sources.
(8) 21 Code of Federal Regulations § 352.10.
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(10) European Commission. Commission Regulation (EU) No
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10
11
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-
Substance Information
-
ECHA,
ASSOCIATED CONTENT
Supporting Information
The Supporting Information is available free of charge on the
ACS Publications website.
Supporting Information includes: structural formulae of glucuron-
ides; commercial reagents and materials (with abbreviations);
syntheses and characterization of products; further details on HR-
MS and UHR-MS conditions, preparation of standard solutions,
chromatographic conditions, estimation of LOQs, and discussion
of enzymatic hydrolysis and MS/MS fragmentation behavior of
analytical standards; exemplary calibration curves.
ECHA
disseminated
dossier,
AUTHOR INFORMATION
Corresponding Author
* E-mail: bury@ipa-dguv.de; Tel.: +49 (0)234 302 4796; Fax:
+49 (0)234 302 4730; ORCID iD: orcid.org/0000-0003-1283-
3133
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENT
The method development was financed by the Chemie
Wirtschaftsförderungsgesellschaft mbH as part of the cooperation
project between the German Federal Ministry for the Environ-
ment, Nature Conservation, Building and Nuclear Safety (BMUB)
and the Verband der Chemischen Industrie e.V. (German Chemi-
cal Industry Association—VCI), managed by the German Federal
Environment Agency (UBA). NMR spectra were recorded by J.
Bienert (MPI BPC); elemental compositions of the 5 new com-
pounds were confirmed by HRMS in full scan mode in the lab of
Dr. H. Frauendorf (Institut für organische und biomolekulare
Chemie, Georg-August-Universität, Göttingen). DAV acknowl-
edges support by the German Research Foundation (FTICR-MS
Facility, INST 256/356-1).
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