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ChemComm
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COMMUNICATION
Journal Name
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6
Scheme 2 Possible mechanisms
Conclusions
In summary, the first synthesis of aromatic isothiocyanates
employing the Langlois reagent as an effective
isothiocyanating agent has been reported. A variety of
synthetically useful functional groups and heterocycles are
tolerated under the reaction conditions, which will be of great
interest to medicinal chemists. The use of Langlois reagent in
place of highly toxic phosgene or thiophosgene provides an
operationally simple, safe, and environmentally benign
synthetic route to aromatic isothiocyanates.
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We thank the Science Technology Program Project of
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