Helvetica Chimica Acta p. 988 - 991 (1988)
Update date:2022-08-05
Topics:
Eichhorn, Thomas A.
Piesch,Steffen
Ried, Walter
The synthesis of new aryl (3,6-dichloro-4-pyridazinyl)ketones 3a-e via Friedel-Crafts acylation of the aromatic compounds 2a-e with 3,6-dichloro-4-pyridazinecarbonyl chloride (1) is described.The ketones 3a-e are cyclized with N,N-dinucleophilic reagents to the 3-aryl-5-chloro-1H-pyrazolo<3,4-c>pyridazines 4a-d, and 3a-c are converted into the 3-aryl-5-chloro-1H-pyrazolo<3,4-c>pyridazin-1-ethanols 5a-c and to the hitherto unknown ring system of the 5-aryl-3-chloro-7,8-dihydro-9H-pyridazino<3,4-e><1,4>diazepines (6a-c).
View MoreSuZhou Bichal Biological Technology CO.,LTD
Contact:+86-512-68051130
Address:NO.32 huoju road HI-TECH Industrial development zone SuZhou China
Jiangsu Allyrise Pharmaceutical Co., Ltd.
Contact:+86-523-86818997
Address:Taizhou,Jiangsu Province,CHINA
Shanghai Anya Chemicals Co.,Ltd
Contact:+86 21 51087925
Address:Room 1101, No.1, Lane 111, Fudu Road, Shanghai, China
lianyungang jinkang pharmaceutical technology co., ltd.
Contact:008651885445517
Address:Jinshan industrial park, Ganyu county, Lianyungang, Jiangsu Province, 222115, China
JIANGSU GRAND XINYI PHARMACEUTICAL CO.,LTD
website:http://www.xypharm.com/
Contact:+86-515-84383317
Address:Chenli Road,Costal Chemical Area Binhai,Yancheng, Jiangsu,China
Doi:10.1021/om00106a011
(1989)Doi:10.1021/ja00188a048
(1989)Doi:10.1002/chem.200802389
(2009)Doi:10.1016/j.tetlet.2020.151899
(2020)Doi:10.1016/j.bmcl.2015.06.082
(2015)Doi:10.1021/jm00118a027
(1988)