Heterocyclic quinones. 17. A new in vivo active antineoplastic drug: 6,7-bis(1-aziridinyl)-4-[[3-(N,N-dimethylamino)propyl]amino]-5, 8-quinazolinedione

DOI: 10.1021/jm00105a007

Source and publish data:

Journal of Medicinal Chemistry p. 38 - 46 (1991)

Update date:2022-07-31

Topics:

Authors:

Giorgi-Renault

Renault Renault

Gebel-Servolles

Baron Baron

Paoletti

Cros Cros

Bissery Bissery

Lavelle Lavelle

Atassi Atassi

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Article abstract of DOI:10.1021/jm00105a007

A series of heterocyclic quinones, 6-substituted and 6,7-disubstituted 4-(alkylamino)-5,8-quinazolinediones, have been synthesized in order to evaluate their in vitro cytotoxicity on L1210 leukemia cells. Among 14 derivatives that have been prepared and s

Full text of DOI:10.1021/jm00105a007

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Article Doi

Heterocyclic quinones. 17. A new in vivo active antineoplastic drug: 6,7-bis(1-aziridinyl)-4-[[3-(N,N-dimethylamino)propyl]amino]-5, 8-quinazolinedione

DOI: 10.1021/jm00105a007

Source and publish data:

Authors:

Article abstract of DOI:10.1021/jm00105a007

Full text of DOI:10.1021/jm00105a007

Products guided by the article

R&D Labs maybe for 120075-63-0

Relevant to this article

Efficient microwave assisted syntheses of 2,5-diketopiperazines in aqueous media

Synthesis of enantiomerically pure diethyl (R)- and (S)-2-hydroxy-3-(1,2,3-triazol-1-yl)propylphosphonates

Molecular recognition of cationic phenothiazinium and phenoxazinium dyes with π-extended 2'-deoxyadenosine nucleotides

The effect of the nitrogen non-bonding electron pair on the NMR and X-ray in 1,3-diazaheterocycles

Diazabicycloalkanes with nitrogen atoms in the nodal positions. 5. Synthesis and some reactions of 2-hydroxymethyl-1,4-diazabicyclo [2.2.2]octane

Alkyl 2-Methyldithiocarbazates in Heterocyclic Synthesis: Preparation of 2-Alkylthio-1,3,4-thiadiazolium Cations and 2-Thioxo-2,3-dihydro-1,3,4-oxadiazole Derivatives