Biocatalytic Knoevenagel reaction 243
Table iii. (Continured).
entry
a
b
Time (h)
Yield (%)b (e/Z)
no reaction
17
18
96
CHO
CHO
O
O
O
96
96
no reaction
no reaction
O
O
O
19
O
CHO
aReaction conditions: a (0.5 mmol), b (0.6 mmol), deionized water (0.05 ml), DMSo (0.95 ml) and BLaP
(70 mg) at 45°C. bYield of the isolated product after chromatography on silica gel and the Z or e
configuration was determined by 1H nMR in comparison with the known compounds.
Declaration of interest: The authors report no
conflicts of interest. The authors alone are respon-
sible for the content and writing of the article. Finan-
cial support from natural Science Foundation
Project of CQ CSTC (2009Ba5051) is gratefully
acknowledged.
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