Journal of Medicinal Chemistry p. 2297 - 2300 (1989)
Update date:2022-07-29
Topics:
Mukherjee
Akhtar
Sharma
Seth
Bhaduri
Agnihotri
Mehrotra
Kamboj
A number of 2,6-dimethyl-3,5-bis(methoxycarbonyl)-4-substituted-1,4-dihydropyridines were synthesized and evaluated for pregnancy-interceptive activity in mated hamsters. Our of 24 compounds, 12, 15, 21, 22, 28, and 34 caused a marked reduction in the number of implantations when administered on days 3-8 postcoitum. In an in vitro competition assay, none of the compounds exhibited noticeable binding affinity for uterine progesterone receptors. The results reported here have helped to identify new leads for developing pregnancy-interceptive agents and the active compounds do not seem to elicit their interceptive effect through receptor-mediated inhibition of progesterone action in hamster uterus.
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Doi:10.1039/c39890000177
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