Journal of the American Chemical Society p. 5778 - 5782 (1989)
Update date:2022-08-04
Topics:
Simic, Michael G.
Jovanovic, Slobodan V.
One-electron oxidation of uric acid generates the urate radical, which was studied in aqueous solution by pulse radiolysis and oxygen-uptake measurements.Acid-base properties of the uric acid radical were determined, i.e., pKa1 = 3.1 +/- 0.1 and pKa2 = 9.5 +/- 0.1.The reaction of the radical with oxygen was too slow to be measured, k < 1E-2 dm3 mol-1 s-1.The one-electron-redox potential vs NHE, E7 = 0.59 V, was derived from the pH dependence of the redox potential, which was fitted trough the values measured at pH 7 and 8.9 and those previously at pH 13.Rapid reactions of uric acid with oxidizing species and peroxy radicals were indicative of uric acid as a possible water-soluble physiological antioxidant.Rapid reaction of uric acid with the guanyl radical indicates that uric acid may also act as a repair agent of oxidative damage to DNA bases.
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