10.1002/chem.201605476
Chemistry - A European Journal
COMMUNICATION
Figure 1. The EPR spectra (X band, 9.7 GHz, RT) of reaction mixture in the
presence of the radical trap DMPO (2.5×10-2 M).
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Scheme 6. Proposed Mechanism.
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In conclusion, a novel and efficient C-H amination is
developed by using a new NH2-reagent. The reaction is
operationally simple, and can be performed in air under mild and
redox-neutral conditions and can be applied to the late stage
modification of bioactive compounds. Preliminary EPR and
control experiments indicate that an amino radical is involved.
Further application of this aminating reagent are undergoing in our
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Acknowledgements
Financial support from National Basic Research Program of
China (973 Program) (No. 2015CB856600), National Natural
Science Foundation of China (21325206, 21632001), National
Young Top-notch Talent Support Program, and Peking University
(BMU20160541) are greatly appreciated. We thank Yiqun Zhang
for reproducing the results of 3o and 5g.
Keywords: Amination • C-H functionalization • Radical • New
reagents • Iron
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