Journal of Medicinal Chemistry p. 2089 - 2092 (1989)
Update date:2022-09-26
Topics:
Temple, Carroll
Rener, Gregory
Racemic ethyl 5-amino-1,2-dihydro-2-methyl-3-phenylpyrido<3,4-b>pyrazine-7-carbamate (1a) has shown antitumor activity in a variety of in vivo experiments.The preparation of the R (9) and S (10) isomers gave compounds with significant differences in potency in several biological tests.
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