Tetrahedron p. 721 - 732 (1989)
Update date:2022-08-05
Topics:
Zylber, J.
Ouazzani-Chahdi, L.
Lefort, D.
Chiaroni, A.
Riche, C.
Primary and secondary electrophilic radicals such as: .CHRCO2CH3 (R=H, CH3, CO2CH3) and tertiary .CCl3 radical were added directly at C-8 of, th model purine compound, caffeine to give the corresponding 8-substituted derivatives in fairly good yields.Unexpected reaction of caffeine with oxy radicals from the initiators (PhCO2., t-BuOO.) gave rise to C-5 substituted 1,3,7-trimethyl-5,7-dihydrouric acid derivatives (C-5-R=CCl3, CH3, C(CH3)2CO2CH3) and to the spirodihydantoin C-8 adduct derivative of caffeine 11.
View MoreQINGDAO NEW FLOURISH INTERNATIOANAL TRADE CO., LTD.
Contact:+86 532 80861829
Address:No. 1, Yinchuan East Road, 266061, Qingdao, China
Contact:0086-22-23410962
Address:17-201, Ningfuli, Shuishanggongyuandong road,Nankai district, Tianjin, China
Lishui Nanming Chemical Co., Ltd
Contact:+86-0578-2134101,2697830
Address:No.19 Tongji Road Shuige Industrial zone
Contact:0571-86821378 ,86820258,56836287,56830923,
Address:Block D ,20F, Tianyuan Building,No.508, Wensan RD, 310013,Hangzhou Zhejiang China
website:http://www.chinabarton.com
Contact:+86-573-82719618
Address:No. 162 Fumin Road, Honghe Town,
Doi:10.1039/CC9960001369
(1996)Doi:10.1016/0022-328X(88)80151-7
(1988)Doi:10.1021/jo00910a035
(1975)Doi:10.1021/jo00901a038
(1975)Doi:10.1016/S0020-1693(02)01302-6
(2003)Doi:10.1039/jr9370002003
(1937)