Beilstein Journal of Organic Chemistry p. 612 - 619 (2017)
Update date:2022-08-04
Topics:
Castán, Alejandro
Badorrey, Ramón
Gálvez
Díaz-De-Villegas
New pyrrolidine-based organocatalysts with a bulky substituent at C2 were synthesized from chiral imines derived from (R)-glyceraldehyde acetonide by diastereoselective allylation followed by a sequential hydrozirconation/iodination reaction. The new compounds were found to be effective organocatalysts for the Michael addition of aldehydes to nitroolefins and enantioselectivities up to 85% ee were achieved.
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