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N
H
N
H
N
H
N
H
O
N
O
Ar
Figure 2. Proposed transition state model.
In conclusion, we first successfully applied the secondary
amine–thiourea bifunctional catalysts with two catalytic sites of
chiral thiourea and L-prolic amide skeleton to catalyze the Michael
addition of isobutyraldehyde to nitroalkenes with good yields (up
to 75%) and excellent enantioselectivities (up to 96% ee) for a vari-
ety of aryl and heteroaryl nitroalkenes. Further studies of the new-
ly developed catalyst model and related catalysts in other catalytic
reactions are currently underway.
Acknowledgments
We are grateful for the financial support from National Natural
Science Foundation of China (20802075) and the Chinese Academy
of Sciences.
Supplementary data
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Supplementary data associated with this article can be found, in
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