Synthesis p. 337 - 340 (1989)
Update date:2022-08-05
Topics:
Walizei, Gul Hassan
Breitmaier, Eberhard
2-Alkoxycarbonylpyrroles and 2-cyanopyrroles 4 are prepared in a one-step synthesis by vinylogous amidation of 3-alkoxyacroleins 1 with glycine esters 2a-c and aminoacetonitrile (2d), followed by base-catalyzed cyclodehydration of the intermediate 3-aminoacroleins 3.The 3-hydroxypropyl function can be introduced into the pyrrole ring by using 3,4-dihydro-2H-pyran-5-carbaldehyde (5) as a cyclic 3-alkoxyacrolein.
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