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LETTER
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(13) General Procedures for the Syntheses of 2-Bromoalk-1-
ene 1 and Alkyne 2
References and Notes
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A mixture of 1,2-dibromoalkane 3 (1.0 equiv) and TBAF (1
M in THF solution, 1.1 equiv or 5.0 equiv) in DMF (0.1 M)
was stirred at 60 °C. The reaction was quenched with sat. aq
NH4Cl, and the reaction mixture was extracted with EtOAc,
concentrated in vacuo, and purified by silica gel column
chromatography to afford 1 or 2.
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