Communication
ChemComm
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In summary, we have developed an efficient method for the
synthesis of diverse substituted 2,30-diindolylmethanes from
propargylic alcohols and indoles. The indole nucleophiles can be
replaced by other carbon or oxygen nucleophiles. Being able to use
economical copper catalyst to promote the hydroamination and
arylation cascade reaction makes this method and the syntheses
of related indole derivatives ideal for both medicinal and process
chemistry.
We thank the University of Wisconsin and NIH (R01GM088285)
for financial support. H.L. thanks Chinese Scholarship Council for
a fellowship and Dr Yu Tang (Tianjin University) for his mentoring.
H.-m.J.G. is a high school student from St. Mark’s School.
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12296 | Chem. Commun., 2014, 50, 12293--12296
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