Chemical and pharmaceutical bulletin p. 861 - 865 (1989)
Update date:2022-09-26
Topics:
Kiyoshima
Sakamoto
Ishikura
Fukagawa
Yoshioka
Naganawa
Sawa
Takeuchi
4''-O-Acyl-, 4''-O-alkyl- and 4''-deoxy-tylosin derivatives were synthesized using 2'-O-acetyl-3'',4''-O-(dibutyl-stannio)tylosin as a synthetic intermediate. The in vitro biological evaluation showed that the new derivatives were active against macrolide-resistant clinical isolates of bacteria and mycoplasmas, and that they were resistant to hepatic esterase.
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