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Scheme 2 Continuous (single pass) copper-catalysed decarboxyla-
tion of propargylic acids (full conversion, isolated yields). Reagents
and conditions: substrates dissolved in MeCN (0.1 M), inductive fre-
quency 15 kHz; yields in batch for 14 (quant, 3 h), 16 (96%, 3 h); con-
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conversion, isolated yield). Reagents and conditions: substrate dis-
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Synlett 2010, No. 13, 2009–2013 © Thieme Stuttgart · New York