Organic & Biomolecular Chemistry
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3. Conclusions
In summary, we have developed a general and practical
method for converting esters to thioesters via C–O bond clea-
vage/weak C–S bond formation. The method is notable for
operationally-simple and general reaction conditions, broad
functional group tolerance and excellent chemoselectivity with
respect to aryl esters and sensitive acyl groups. This approach
tolerates a range of functional groups that are incompatible
with previous methods. The utility has been demonstrated in
late-stage thioesterification, sequential bond activation and
large scale synthesis. We anticipate that studies on the reversal
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acid reactivity in various aspects of synthetic chemistry. Future
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928.
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Conflicts of interest
There are no conflicts to declare.
14 F. Bie, X. Liu, Y. Shi, H. Cao, Y. Han, M. Szostak and C. Liu,
J. Org. Chem., 2020, 85, 15676–15685.
Acknowledgements
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We thank Zaozhuang University, Shandong Lunan Coal
Chemical Research Institute of Engineering and Technology,
Zaozhuang Science and Technology Development Program
(no. 2018GH19), NSF (CAREER CHE-1650766) and Rutgers
University for financial support. We thank the Wroclaw Center
for Networking and Supercomputing (no. WCSS159). We thank
Md. Mahbubur Rahman (Rutgers University) for helpful dis-
cussions. The Bruker 400 MHz spectrometer used in this study
was supported by College of Chemistry, Chemical Engineering
and Materials Science at Zaozhuang University.
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