ACS Catalysis
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similar electrochemical oxidation process. The H2 was re-
leased in cathode via the electrochemical reduction of protons.
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Overall, an ECAD of N-heterocycles is developed using
TEMPO as the organo-electrocatalyst. The dehydrogenation of
N-heterocycles and release of H2 are achieved in one system
under oxidant-free conditions. The mild condition, high activi-
ty and broad substrate scope of the strategy enabled the pro-
cess an appealing route for the synthesis of various N-
heteroarenes with great synthetic values. Mechanistic studies
indicated the imine intermediate served as the intermediate in
this transformation. The synthetic applications and gram-scale
experiments further demonstrated the potential usage of our
reaction.
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ASSOCIATED CONTENT
Supporting Information.
The Supporting Information is available free of charge via the
ed data about scale-up reaction and characterization (PDF).
AUTHOR INFORMATION
Corresponding Author
* Corresponding author, E-mail: aiwenlei@whu.edu.cn.
Author Contributions
‡ These authors contributed equally to this work
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENT
This work was supported by the 973 Program (2011CB808600,
2012CB725302, 2013CB834804), the National Natural Science
Foundation of China (21390400, 21272180, 21302148, 2109343 and
21402217), and the Research Fund for the Doctoral Program of High-
er Education of China (20120141130002) and the Ministry of Science
and Technology of China (2012YQ120060) and the Program for
Changjiang Scholars and Innovative Research Team in University
(IRT1030). The Program of Introducing Talents of Discipline to Uni-
versities of China (111 Program) is also appreciated.
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