Organic Letters
Letter
̌
Vrab
́
el, V.; Sestak
́
, S.; Rendic,
́
D.; Tognetti, V.; Joubert, L.; Daïch, A.
ruthena-cycle J that cyclized easily to form the lactone 24a
(Scheme 8). Spectral data of lactone 24a are identical with the
declared spectra of lactam 23a in the literature.10 As the authors
furnished only the HRMS analysis without elemental analysis
for lactam 23a, the structure of lactone 24a cannot be
reasonably excluded (see SI for 10 other corrected structures).
In conclusion, during our investigations on the synthesis of
tylophorine (A) and cryptopleurine (B) analogues, we have
prepared standards of dihydropyrrolo[1,2-b]isoquinolinones
and pyrido[1,2-b]isoquinolinones as advanced platforms for
molecular diversity. Upon checking the literature, we were
highly surprised by the spectral data attributed to these
products, obtained by a Pt(II)-catalyzed carbocyclization of
benzaldehyde containing an alkyne-nitrile functionality.10
Careful reexamination of the reported procedure with some
substrates resulted in the structure revision of a set of
compounds from fused lactams into new and scarce
isochromenes. In the same context, the initially assigned
spiro-lactams which were obtained from the same intermediates
generated by benzaldehyde containing an alkyne-nitrile
functionality were also revised into spiro-lactones. The
confirmation of these new structures was based on an
unambiguous chemical synthesis of certain isochromenes and
spiro-lactones and via IR analysis and thorough NMR studies as
well as single crystal X-ray analysis.
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ASSOCIATED CONTENT
* Supporting Information
The Supporting Information is available free of charge on the
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AUTHOR INFORMATION
Corresponding Authors
■
ORCID
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
■
This work was supported by the Grant Agency of the Slovak
Republic (No. 1/0371/16). Authors also thank the scientific
council of University Le Havre-Normandie for technical
support. This letter was created also with the support of the
̌
̌
MSVVaS of the Slovak Republic within the project (No.
26240220084) cofunded by the European Regional Develop-
ment Fund.
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Org. Lett. XXXX, XXX, XXX−XXX