Research on Chemical Intermediates p. 3105 - 3110 (2013)
Update date:2022-07-31
Topics:
Gu, Ning
Yang, Jiabin
Wang, Peng
Li, Lushen
Chen, Yang
Ji, Min
The Wittig-Horner reaction is a classic method to get alkenes by reaction phosphonates with carbonyl compounds. In this study, it was used for the synthesis of the anticancer drug neratinib. In this method, ethyl diethoxyphosphinylacetate and dimethylaminoacetaldehyde diethylacetal, replacing (E)-4-(dimethylamino)but-2-enoyl acid hydrochloride and oxalyl chloride, were used to synthesize the 6-position side chain of neratinib.
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