Journal of Medicinal Chemistry p. 1582 - 1590 (1990)
Update date:2022-08-05
Topics:
Rosenberg, Saul H.
Dellaria, Joseph F.
Kempf, Dale J.
Hutchins, Charles W.
Woods, Keith W.
et al.
A series of low-nanomolar renin inhibitors containing novel C-terminal heterocycles has been designed by formally cyclizing the C-terminus of a glycol-based inhibitor to the second hydroxyl.Molecular modeling suggests that the heterocyclic oxygen hydrogen
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